ABSTRACT
Indroduction: Thrombotic complications leading to cerebrovascular events occuring in conjunction with Covid-19 vaccination though rare, is well-documented. Moyamoya Angiopathy is a progressive intracranial vasculopathy leading to recurrent strokes. Case presentation: We present two index cases of young patient presenting with stroke and TIA following Covid-19 vaccination (COVISHIELD) leading to unmasking of Moyamoya Angiopathy. Conclusion(s): Arterial stroke following Covid-19 vaccination is documented, but uncommon. However, in the background of a vasculopathy, it may not be so rare. Moyamoya Angiopathy has been closely studied in the model of inflammatory pathophysiology in genetically predisposed patients leading to progressive vaso-occlusive disease. Few reports of Covid-19 infection potentiating Moyamoya Angiopathy symptoms are also documented. Thus, as an extrapolation of the inflammatory etiopathogenesis of Moyamoya Angiopathy, Covid-19 vaccination can similarly affect the Moyamoya symptomatology. These two index cases open new lines of enquiry regarding the interplay of Covid-19 vaccination and neurological destabilization in patients with underlying vasculopathy of inflammatory pathophysiology.Copyright © 2022
ABSTRACT
In order to promote public health response to COVID-19, digital technologies are being used around the world. These include population surveillance, case identification, contact tracing, and intervention assessment based on mobility data and public communication. These rapid responses are made possible by the millions of mobile phones in use, massive online data sets, connected devices, low-cost computer resources and machines, and advances in natural language processing. To achieve this goal, a comprehensive review of digital innovations for COVID-19 response to public health around the world is being conducted, including a look at their limitations and implementation obstacles such as legal or ethical issues, privacy concerns, and organizational and personnel issues. We investigate the need for international strategies to improve pandemic control and future preparedness for COVID-19 and other infectious diseases through the regulation, assessment, and use of digital technologies, as well as the need for international strategies to regulate, assess, and use digital technology in pandemic management. © 2022 Elsevier Inc. All rights reserved.
ABSTRACT
Deep learning involves using deep neural networks with multiple hierarchical hidden layers of nonlinear processing of input to allow complex patterns to be discovered from vast volumes of raw data. Performance is improved through adjusting, optimizing, and regulating hyperparameters. An unsupervised study can find patterns in the data when there are no labels or distribution of probability in data. The study of genomic sequencing and genome expression is typically characterized by deep learning. Prediction of genomic profiles is based on around 1000 programs of the NIH Integrated Network (LINCS) that have dramatically surpassed linear regression in both RNA-seq findings and microarrays in terms of predictive precision. To predict the transcription factor binding sites, inputs taken from Deep CNN have been encrypted. By retrieving higher levels from those in raw nucleotides, the deeper model would make categorization more accurate. Genetic variations may affect the transcription of DNA and mRNA. © 2022 Elsevier Inc. All rights reserved.
ABSTRACT
Immunisation is the procedure of providing a vaccine to a person in order to protect him or her against disease. This process has been widely recognized and adopted as one of the world's most successful and cost-effective health interventions. Vaccines have been saving millions of lives worldwide from deadly infectious diseases and viruses, such as hepatitis, measles and polio. However, the COVID outbreak in the late 2019 has witnessed huge devastation on the global health front. For now, vaccine is the only cost-effective health intervention to control the spread of virus and completely eradicating it. Technological breakthroughs are making a significant contribution to the improvement of healthcare. Blockchain technology is one example of such a disruptive technology. Blockchains have the potential to improve the healthcare system in a variety of ways. In this paper, we have thoroughly discussed how we can create vaccine awareness across the globe by focusing on parents, healthcare workers, frontline workers, policymakers, media, and ultimately how everyone must work together to ensure that every individual in every country gets the vaccine. We also discussed how blockchain technology may be applied to many sectors of healthcare and the benefits it can provide in terms of enhancing global network healthcare systems. © 2022 IEEE.
ABSTRACT
Malaria is a major threat to global health and continues to claim lives of many people each year, especially in developing countries. Xanthium strumarium L., is used by traditional health practitioners in the management of malaria fever in North East India. Bioassay guided fractionation of X. strumarium L. extracts, led to the isolation of five compounds from the aerial part and fruit of Xanthium strumarium, namely, stigmasta-5,22-dien-3beta-ol (1), xanthinosin (2), stigmasterol-3-O-beta-D-glucopyranoside (3), oleic acid (4) and (E)-2, 3-dihydroxypropyl-octadec-9-enoate (5). Antimalarial potential of isolated compounds were evaluated against 3D7 strain of Plasmodium falciparum by schizont maturation inhibition assay method. The structures of isolated compounds were established by HR-MS, NMR experiments and comparison from literature data. Compounds 2 and 3 showed significant antimalarial properties against 3D7 strain of P.falciparum with IC50 value 27.25 and 7.14M respectively. The antimalarial activities of xanthinosin (2) and stigmasterol-3-O-beta-D-glucopyranoside (3) lend credence to the application of X. strumarium against malaria and thus provides new template for development of antimalarial molecules. X. strumarium has also scope for the development of antimalarial phyto-pharmaceutical with five identified compounds with P.falciparum inhibitory activity as per the drugs and cosmetics act of India (1940, amended 31st December 2016).
ABSTRACT
Coronavirus condition (COVID-19) is a contagious illness brought on by a freshly discovered Coronavirus. Most individuals contaminated with the COVID-19 infection will certainly experience moderate to modest respiratory system health problems and recoup without needing unique therapy. Older people and those with underlying clinical problems like cardiovascular disease, diabetic issues, persistent respiratory conditions, and cancer are more likely to create a significant health problem. Aim and Objective: This paper gives the best way to prevent and reduce transmission is to be well educated about the COVID-19 infection, its causes, and its spread. Protect your own and others from infection by cleaning your hands or using an alcohol-based rub frequently and not touching your face. The COVID-19 infection spreads out primarily via beads of saliva or dis-charge from the nose when an infected person coughs or sneezes, so it is vital that you additionally exercise breathing rules (for instance, by coughing right into a flexed elbow joint). Right now, there are no detailed vaccinations or therapies for COVID-19. Nevertheless, there are several ongoing professional trials assessing capacity treatments. Method: The study aimed to develop a statistical model to predict how the cases are growing exponentially in various parts of the world. Even after starting from a low base, there is no proper statistical analysis of cases we can expect. It is an ambiguous thing that numbers of cases are exponentially increasing. We have analyzed the mortality rate, the number of deaths per country, and the number of recovery cases. Conclusion: By comparing the statistical analysis of confirmed cases vs. deaths within a short period, nCov-19 affected the most compared with Zoonotic viruses. The coronavirus disease remains to spread out throughout the globe, adhering to a trajec-tory that is challenging to predict. The health, altruistic, and socio-economic policies have taken on by nations will certainly figure out the rate and stamina of the healing. There has to be a global human-centred reaction that is based on solidarity. © IJCRR.